COMT and Mental deterioration: For example, the Catechol-O-methyltransferase genotype was found to be related to executive-attention function (Foltynie et al., 2004; Williams-Gray et al., 2009; Fang et al., 2019), and the apolipoprotein E genotype is related to cognitive decline (Tropea et al., 2018), especially the posterior cortical dysfunction (Williams-Gray et al., 2009), in the PD population.