Many clinical factors have been used to predict the survival of patients with CRLM after hepatectomy, including the tumor size and number of lesions [8, 12–14], carcinoembryonic antigen (CEA) level [12, 15], node-positive primary disease [12, 16], clinical risk score (CRS) [17–19], and resection margin involvement [16, 20]. Here, CEACAM5 is linked to neoplasm.