The integrative therapy group had relatively older patients (P=0.005), higher proportion of combined renal insufficiency (P < 0.001), higher test Cr level (P=0.04), higher Hs-CRP level (P=0.007), higher NT-proBNP (P=0.019) level, more patients with poorer heart function (cardiac function class IV) (P=0.004), and relatively longer hospital stays than the conventional therapy group (P=0.003). The gene discussed is CRP; the disease is Renal insufficiency.