These values were significantly reduced in the donepezil and EA groups in comparison with those in the AD group, particularly in the EA group (p value in the donepezil group was 0.001 for IL-1β, 0.001 for IL-6, and 0.001 for TNF-α; p value in the EA group was 0.001 for IL-1β, IL-6, and TNF-α). The gene discussed is IL1B; the disease is Alzheimer disease.