Expression of these proinflammatory markers was significantly reduced as compared to the AD group in donepezil and EA groups (p values were 0.003 and 0.001 for IL-1β at frontal lobe; p values were 0.002 and 0.001 for IL-1β at hippocampus; p values were both 0.001 at the frontal lobe; p values were 0.008 and 0.001 for IL-6 at the hippocampus; p values were 0.001 and 0.001 for TNF-α at the frontal lobe; p values were both 0.001 for TNF-α at the hippocampus). This evidence concerns the gene IL6 and Alzheimer disease.