In the crude Cox regression only obesity (HR 3.923, p=0.015), Sa/FiO2 (HR 0.987, p=0.032), GMCSF (HR 1.975, p=0.034), IL-15 (HR 1.252, p=0.023) and zonulin levels (HR 1.106, p=0.001) were found to be significant (Table 5). Here, HP is linked to obesity due to melanocortin 4 receptor deficiency.