Interestingly our group has identified, at the C-terminal part of the ERα hinge region (amino acids 295-311) a decaheptapeptide, named ERalpha17p, which can be released after proteasomal degradation of ERα and possesses estrogenic (25, 27) and pro-apoptotic (29) actions and modulates the migratory activity of human breast cancer cells in vitro (30) by interacting with specific isoforms of ERα (31). The gene discussed is ESR1; the disease is breast cancer.