Ribosomal protein S6 kinase A1 (Rps6ka1), pyruvate dehydrogenase kinase 1 (Pdk1), abscisic acid insensitive 2 (Abi2), and AKT serine/threonine kinase 1 (Akt1) were upregulated in the ROS signal pathway, while the HIF-related cancer signal converged on Notch3, the SWT/SNF (switch/sucrose non-fermentable) chromatin remodeling gene (Smarca4), zinc finger homeobox 3 (Zfhx3), and telomerase reverse transcriptase (Tert). The gene discussed is NOTCH3; the disease is cancer.