In addition, MQEP inhibited the activation of the RANKL/RANK/OPG signaling pathway, reduced RANKL expression, and reversed the decrease in OPG expression caused by long-term GC use, thus reducing the ratio of RANKL/OPG and causing the negative balance of bone resorption over bone formation, bone loss, and osteoporosis to be recovered to some extent. This evidence concerns the gene TNFRSF11B and osteoporosis.