IL1A and systemic inflammatory response syndrome: Thus, inflammatory mediators may play an important role in early diagnosis and plasma levels of cytokines like IL-1, IL-2, IL-6, IL-12, IL-8, IL-4, IL-10, IL-17, IL-13, TNF-α, IFN-γ, and TGF-β, complement C3a and C5a, leukotrienes, prostaglandins, thromboxane, and immune cells might be diagnostic as well as prognostic [72] for SIRS.