AGER and Sepsis: Matsumoto et al. [100] reported that compared to control, patients with sepsis had significantly increased levels of soluble (s) RAGE and were significantly associated with Acute Physiology and Chronic Health Evaluation II (APACHE II), Sequential Organ Failure Assessment (SOFA), and International Society of Thrombosis and Haemostasis (ISTH) overt disseminated intravascular coagulation (DIC) scores.