MYH14 and cardiac hypertrophy: Although OM is termed by most studies as a myosin activator, the word activator actually comes from the dated understanding of OM’s effects in terms of improving cardiac contractile function but does not quite accurately describe the molecular effect of OM on myosin biomechanics, as chronically activated myosin activity would lead to pathological cardiac hypertrophy (Malik et al., 2011).