Recently, a nano-delivery system for dual targeting tumor therapy with intracellular RNA and nuclear DNA was developed by Ma and his colleagues, to achieve intracellular co-delivery of cis-platinum pro-drugs (DSP) and cytotoxic protein RNase A. They used large-pore mesoporous silica-coated β-NaYF4:20%Yb, 2%Er@β-NaGdF4(UCS) nanoparticles as carriers, which were prepared according to their previous work (Ding et al., 2018). Here, RNASE1 is linked to neoplasm.