Jin et al. demonstrated that bFGF significantly promoted the production of collagen and elastin from elastin-expressing BMSCs in vitro and in vivo, and co-injection of PLGA-loaded bFGF NP and elastin-expressing BMSCs into the PFD rats significantly improved the outcome of urodynamic tests (Jin et al., 2016a). This evidence concerns the gene FGF2 and polyostotic fibrous dysplasia.