According to this method, we estimated the following top five frequencies of autosomal recessive NSHL per gene per 1,000 people: GJB2: 0.25; STRC: 0.1; OTOA: 0.05; TMPRSS3: 0.02, and OTOF: 0.01. The gene discussed is TMPRSS3; the disease is nodular sclerosis classical Hodgkin lymphoma.