ABCA1 and brain injury: Their investigation has revealed that ischemic preconditioning as an endogenous neuroprotective process promotes expression of ATP-binding cassette subfamily A member 1 (ABCA1), suppresses miR-135-5p expression, decreases the Bax/Bcl2 proportion and activates caspase-9 and caspase-3, thus protecting neural cells against mitochondria-dependent apoptosis and subsequent brain injuries (Sung et al., 2021).