At the meantime, some other proteins such as collagen family (COL4A3, COL8A1, COL10A1, COL15A1), matrix metallopeptidase (MMP2, MMP9, MMP20), and toll like receptor (TLR2, TLR3, TLR4) were also reported to be associated with AMD. Here, COL10A1 is linked to age-related macular degeneration.