At the meantime, some other proteins such as collagen family (COL4A3, COL8A1, COL10A1, COL15A1), matrix metallopeptidase (MMP2, MMP9, MMP20), and toll like receptor (TLR2, TLR3, TLR4) were also reported to be associated with AMD. This evidence concerns the gene COL15A1 and age-related macular degeneration.