C3 and age-related macular degeneration: There were 7 genes belonged to AMDgset, including C3, ELN, TF, FLT1, CFH, VEGFA and FBLN5 (Stone et al., 2004; Fang et al., 2009; Anderson et al., 2010; Yamashiro et al., 2011; Wysokinski et al., 2013; Owen et al., 2014), indicating our results identified many novel genes that are potentially associated with AMD.