Xiang et al. (2021) reported that the lncRNA PINT87aa was upregulated in senescent HCC cells and could induce cell cycle arrest by blocking FOXM1-mediated PHB2. Mittermeier et al. (2020) described the characteristics and functions of cellular senescence in the development of novel drug targets for HCC therapies. Karakousis et al. (2020) suggested that hepatitis B is a link between cellular senescence and HCC development. The gene discussed is PHB2; the disease is hepatitis B virus infection.