The analysis of the enrichment of the hallmark gene set indicated that many pathways closely related to tumor progression were activated in the high-risk group, such as epithelial–mesenchymal transition, IL2-STAT5 signaling, PI3K-AKT-MTOR signaling, and WNT β-catenin signaling (Figures 5A–D). The gene discussed is AKT1; the disease is neoplasm.