Ectodermal dysplasias resulting from a dysfunctional p63 protein, in particular ankyloblepharon-ectodermal dysplasia-cleft lip/palate (AEC) syndrome and ectrodactyly-ectodermal dysplasia-cleft lip/palate (EEC) syndrome, are characterized by typical tissue defects. This evidence concerns the gene TP63 and ectodermal dysplasia syndrome.