A valid and innovative 11-lipid metabolism gene signature model was constructed to predict the prognosis of CRC patients as an independent risk factors, including GGT5, ASAH1, HMGCL, CD36, DPM2, ACOX1, ANGPTL4, INSR, ADIPOQ, ALDH1A3, and MMP1. This evidence concerns the gene ALDH1A3 and colorectal carcinoma.