In this study, a 11-lipid metabolism-related gene signature was established and showed improved prediction of OS for CRC patients, including GGT5, ASAH1, HMGCL, CD36, DPM2, ACOX1, ANGPTL4, INSR, ADIPOQ, ALDH1A3, and MMP1. The gene discussed is ACOX1; the disease is colorectal carcinoma.