And the top 10 significantly downregulated pathways were the peroxisome proliferator-activated receptor (PPAR) signaling pathway, Non-alcoholic fatty liver disease (NAFLD), Peroxisome, Propanoate metabolism, Fatty acid metabolism, Carbon metabolism, Alzheimer’s disease, Parkinson’s disease, Oxidative phosphorylation, and Citrate cycle (TCA cycle) (Figure 2E). Here, PPARA is linked to early-onset autosomal dominant Alzheimer disease.