CD274 and neoplasm: Research has shown that HCP5 promoted lung adenocarcinoma metastasis via the miR-203/SNAI axis and tumor growth and upregulated the expression of PD-L1/CD274 via a competing endogenous RNA mechanism of sponging miR-150–5p, and these were also consistent with our findings (Jiang et al., 2019; Xu et al., 2020).