Interestingly, the 7 MTRs that included CEBPE, ELK3, LMO2, RXRA, STAT1, TFEC, and VDR are also up-regulated DEGs in PAH, and the 4 MTRs that included FOXJ3, FOXK1, RUNX3, and ZNF219 are also down-regulated DEGs in PAH. This evidence concerns the gene RUNX3 and pulmonary arterial hypertension.