We identified 12 MTRs (STAT1, STAT2, CEBPE, RXRA, TFEC, ELK3, VDR, NFYC, LMO2, SPI1, GATA1, and IRF1) which are associated with the interaction of up-regulated DEGs in PAH (Figure 4A). This evidence concerns the gene IRF1 and pulmonary arterial hypertension.