Interestingly, we found that the expression of RPS27A, MAPK1, STAT1, RPS6, FBL, RPS3, RPS2, and GART hub genes are positively correlated with hypoxia (ssGSEA score of hallmark hypoxia gene set) in the PAH (Spearman’s correlation test, p < 0.05) (Figure 7A). Here, RPS27A is linked to pulmonary arterial hypertension.