Also, we identified 12 MTRs (TAF1, FOXJ3, KLF17, ZNF219, TP53, TAF7, PML, STAT5A, MAFB, ZBTB33, FOXK1, and RUNX3) which are associated with the interaction of down-regulated DEGs in PAH (Figure 4B). This evidence concerns the gene RUNX3 and pulmonary arterial hypertension.