Also, the top 25 (The lowest combined effect size) down-regulated genes, including MYLIP, DNAJB1, MGAT4A, PIK3IP1, ARL4C, CAMK4, FCGBP, RORA, HSF2, ZNF256, OXNAD1, DUSP2, PHC3, and CAMK2N1 (Table 3), which are the number of the blood-derived down-regulated transcriptomes, linked with the pathogenesis of PAH, lung diseases, and cardiovascular diseases (Lenna et al., 2013; Zhu et al., 2015; Valisno et al., 2021). The gene discussed is ZNF256; the disease is pulmonary arterial hypertension.