Besides the modulation of the SI architecture and changes in the number of secretory cells, a decrease in the frequency of intestinal stem cells as well as a decrease in the Lgr5-positive tumor area was detected in ApcMin/+ mice with IECs-specific deletion of Csf1r. Furthermore, the number and mean size of tumoroids that could be derived from Csf1r-deficient adenomas was decreased. Here, LGR5 is linked to neoplasm.