MIR34A and adenoma: However, in adenomas from Csf1r/Mir34a-deficient mice ApcMin/+ mice only 15 genes were significantly up- and 17 genes were down-regulated, indicating that the gene expression changes observed in Mir34a-deficient adenomas were largely abrogated by the concomitant deletion of Csf1r (Fig. 6B, Supplementary Table S12).