In cell cycle pathway, several well-known cancer related genes were more frequently altered in HAS comparing to non-HAS, including TP53 (73% vs 51%, P = 0.040), CDK12 (33% vs 6%, P = 0.001), CCNE1 (27% vs 8%, P = 0.024), and BRCA2 (17% vs 3%, P = 0.034). The gene discussed is TP53; the disease is cancer.