qRT-PCR results showed that CD86 expression of M1 phenotype marker in the αAPOE group was significantly higher than that in the control group after the addition of cancer cell (HCT116 -CRC, HGC27-GC, LM3-HCC) supernatant to TAM cells, while the expression of C1QC,CCR2, and ARG1 of M2 phenotype was significantly lower than that in the control group (Figure 6B). Here, C1QC is linked to cancer.