qRT-PCR results showed that CD86 expression of M1 phenotype marker in the αAPOE group was significantly higher than that in the control group after the addition of cancer cell (HCT116 -CRC, HGC27-GC, LM3-HCC) supernatant to TAM cells, while the expression of C1QC,CCR2, and ARG1 of M2 phenotype was significantly lower than that in the control group (Figure 6B). The gene discussed is CCR2; the disease is cancer.