PRKDC and cancer: To connect the activation of DNA-PK, AKT and Notch1, there were abundant studies verifying that DNA-PKcs activation results in AKT-Ser473 phosphorylation in response to DNA damage 24 and the intertwined relationship between Notch1 and the PI3K/AKT axis was also reported in many researches about the signaling transduction in cancer 25.