In their research on head and neck squamous cell carcinoma (HNSCC), Sang H Lee et al. 44 demonstrated that the constitutive activation of NICD promoted CSC traits in differentiated HNSCC cells; moreover, the downregulation of Notch1 signaling attenuated the CSC traits and enhanced the resistance of HNSCC cells to cisplatin. This evidence concerns the gene NOTCH1 and head and neck squamous cell carcinoma.