SPC25 and hepatocellular carcinoma: Consistently, the mRNA expression level of SPC25 was significantly upregulated in 37 paired HCC samples relative to the adjacent nontumorous tissues (Fig. 1C) and was also upregulated in HCC cell lines (HepG2, BEL7402, SK-Hep1, Huh7, Hep3B and SMMC-7721) compared to normal liver cell line (LO2) (Fig. 1D).