Similarly, we found that SNHG16 was significantly upregulated in CRC cell lines (Fig 1I); moreover, we detected the highest expression level of SNHG16 in HCT116 cells and the lowest expression levels of SNHG16 in DLD1 cells; thus, these two cell lines were selected for further research. This evidence concerns the gene SNHG16 and colorectal carcinoma.