Zhang et al. have suggested that IL-6 (interleukin-6) secretion by vCAFs (vascular cancer-associated fibroblasts) significantly enhances the malignancy of ICC cells through IL-6/IL-6R axis interaction between CAFs and tumor cells, while exosomal miR-95p derived from ICC cells can induce IL-6 expression in vCAFs 18. Here, IL6R is linked to intrahepatic cholangiocarcinoma.