G6PD and neoplasm: To explore the effects of Trx-1 and G6PD inhibition on tumor growth, we used dehydroepiandrosterone (DHEA, an inhibitor of G6PD) 29, 1-methylpropyl 2-imidazolyl disulfide (PX-12, an inhibitor of Trx-1) 30 and combination with 2DG to treat CRC xenografts in nude mice.