By detecting the expression of GRP78 protein in colorectal cancer cells intracellularly and on the membrane surface, we found that EGCG could convert cellular constitutive UPR into endoplasmic reticulum stress and induce apoptosis by promoting the intracellular accumulation of GRP78 and reducing membrane content (Figures 4, 5(c), and 5(d)), which is consistent with the result of Simona [21]. Here, HSPA5 is linked to colorectal cancer.