In an experimental model of sepsis-associated encephalopathy (SAE), BBR targeted HMGB1/RAGE signaling to suppress the quantity of inflammatory events of cell factors and astrocyte activation in the cerebrum of SAE mice, thereby alleviating cognitive impairment caused by sepsis (Shi et al., 2021) Moreover, septic cardiomyopathy (SCM) is the most common type of sepsis-related organ dysfunction. Here, HMGB1 is linked to Sepsis.