Furthermore, MeCP2-mediated neurotoxicity may also contribute to neuropsychiatric disorders (Russell et al., 2007; Dastidar et al., 2012; Montgomery et al., 2018) and participate in METH-induced behavioral disorders in rodents (Lewis et al., 2016; Wu et al., 2016; Fan et al., 2020). This evidence concerns the gene MECP2 and Atypical behavior.