INS and hyperandrogenism: Adipose tissue is one of the major targets for insulin, and an increasing number of evidence indicate that the function and morphology of adipose tissue are aberrant in PCOS patients, androgen excess can cause adipocytes hypertrophy, and both adipose tissue hypertrophy and hyperandrogenism are related to IR (Goodarzi et al., 2011; Barber and Franks, 2013).