MRC1 and colitis: About M1/M2 Macrophage Polarization, Kang, et al. (Kang et al., 2021b) the research found that curcumin significantly downregulated the percentage of M1 macrophage CD11b+F4/80+iNOS+ in colitis mice and significantly upregulated the percentage of M2 macrophage CD11b+F4/80+CD206+ and CD11b+F4/80+CD163+ macrophages, suggesting curcumin interfering with the process of experimental colitis effectively by regulating the balance of M1/M2 macrophage polarization.