However, in conditions of IR and diabetes, due to the lack of regulation of insulin signaling, overactive FoxO1 continues to promote gluconeogenesis in an uncontrolled manner, leading to hyperglycemia and ultimately participating in the occurrence of diabetes and its complications and development (Cheng and White, 2011; O-Sullivan et al., 2015). The gene discussed is FOXO1; the disease is Hyperglycemia.