CASP3 and familial dilated cardiomyopathy: Overactivated FoxO1 can also promote the expression of inducible NO synthase in DCM, and further induce the nitrosylation of target proteins such as glyceraldehyde-3-phosphate dehydrogenase and caspase-3, leading to post-hyperglycemia myocardial cell death and myocardial dysfunction (Xin et al., 2017).