AKT1 and ischemic stroke: Some studies suggested that ischemia postcondition mitigated ischemic stroke by suppressing autophagy via promoting the phosphorylation of AKT and mTOR (Yang et al., 2019; Wang H. et al., 2020; Wang M. M. et al., 2020; Meng et al., 2021), while others revealed that the poststroke treatment ameliorated CIRI through inhibiting autophagy via suppressing the phosphorylation of AKT, AMPK, and mTOR (Wang J. F. et al., 2018; Zhang et al., 2020a; Ma et al., 2020; Liu N. et al., 2021; Yang et al., 2021; Zhang et al., 2022).