Meanwhile as a competitive endogenous RNA of sponge miR-138-5p, lncRNA-KLF3-AS1 mediates the expression of sirtuin 1 (SIRT1) and inhibits the activation of NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammatory bodies and, thus, regulates the pyroptosis of cardiomyocytes and the progression of miocardial infarction (MI). This evidence concerns the gene SIRT1 and myocardial infarction.