ARAF, as one isoform of the RAF family of kinases, has been proved to have an obligatory role in promoting MAPK activity and cell migration in a cell type-dependent manner, and ARAF mutations were identified in various tumor types which associated with resistance to RAF inhibitors (Mooz et al., 2014; ARAF Mutations Limit Response to RAF Dimer Inhibition, 2021). This evidence concerns the gene ARAF and neoplasm.