The top one hub protein AKT1, as one isoform of protein kinase B (PKB or AKT), has been reported to be involved in many tumor growth-related biology processes such as cell proliferation, apoptosis, growth, metabolism, and tumor angiogenesis and inflammatory cell infiltration by regulating mTOR, GSK3, BAD, p27KIP1, FoxO, and MDM2 signaling (Somanath et al., 2009; Hers et al., 2011; Fruman and Rommel, 2014; Mundi et al., 2016). Here, MDM2 is linked to neoplasm.