PCBP1, with the most interaction with the relapse-associated AS events in the core SFs, was identified as an intracellular immune checkpoint for maintaining the functions of effector T cells in tumor immunity and has been reported to inhibit HCC cell invasion by regulating the alternative splicing of CD44 (Zhang et al., 2010; Ansa-Addo et al., 2020). The gene discussed is CD44; the disease is hepatocellular carcinoma.