SETMAR-62996-AA, SERBP1-3355-AA, and COMT-61102-AA in AS type of AA; TAF6-80899-AD, C6orf1-75778-AD and RPS16-49830-AD in AS type of AD; TJP2-86533-AP, SERPIND1-61191-AP, and SERPIND1-61190-AP in AS type of AP; SUFU-12963-AT, AP1S2-88571-AT, and AP1S2-88569-AT in AS type of AT; FAM98C.49642.ES, COMMD4-31852-ES, and PRDX5-16639-ES in AS type of ES; SYNGR2-43774-RI, CLU.83171.RI, and RNASEH2C.16916.RI in the AS type of RI were the top three AS events in each AS type. The gene discussed is AP1S2; the disease is alkaline phosphatase measurement.