TLR4 and endothelial dysfunction: Triggering receptors expressed on myeloid cell (TREM)-1 and toll-like receptor (TLR)-4 play a critical role in NIH, vessel remodeling, cellular inflammation, migration, and proliferation of VSMCs, endothelial dysfunction, and atherosclerotic plaque formation and targeting TREM-1 and TLR-4 attenuate inflammation, plaque formation, thrombosis, and prevent restenosis [9, 18–23].