Ketoacidosis, acute kidney injury, dyslipidemia, hypoglycemia in patients taking insulin, hypotension (especially in patients taking diuretics, ARBs, or ACE-inhibitors), genital mycotic infections, hypotension (especially in patients taking ACE-inhibitors, ARBs, or diuretics), and, very rarely, peripheral amputations and Fournier gangrene [63] are some of the side effects of empagliflozin [54,56]. The gene discussed is ACE; the disease is diabetes mellitus.