As Cox's proportional hazards regression model showed that, Urban residence(aHR) = 0.45, 95%CI:0.29–0.68, p < 0.001], Baseline WHO stage 2 (aHR = 0.28, 95%CI:0.12–0.64, p = 0.002),Baseline CD4 count ≥301 (aHR = 0.39, 95%CI = 0.16–0.93, p = 0.034),TB symptoms (aHR = 1.63, 95%CI = 1.03–2.58, p = 0.037), and AZT+3 TC + NVP/EFV regimen (aHR = 1.757, 95%CI:1.14–2.71, p = 0.011) were found to be significant predictors for ARV regimen change (Table 3) (see Table 4). The gene discussed is CD4; the disease is tuberculosis.