Hazard curves plots of the place of residence [Log Rank (Mantel-Cox) (p = 0.002)], baseline functional status [Log Rank (Mantel-Cox) (p = 0.003)], baseline WHO stage [Log Rank (Mantel-Cox) (p = 0.001)], baseline CD4 count [Log Rank (Mantel-Cox) (p = 0.009)], ART regimen [Log Rank (Mantel-Cox) (p < 0.001)] and baseline TB screening symptoms [Log Rank (Mantel-Cox) (p < 0.001)] were statistically significantly influenced the time to change ARV regimen (Additional file 1–6). Here, CD4 is linked to tuberculosis.