The synthesised compounds were subjected to: spectroscopic analysis (IR, 1H NMR, Dept-Q NMR, and Mass) and elemental analysis to confirm the chemical structures, measurement of their AChE and BuChE inhibitory activities to evaluate their effect on AD, assessment of antineuro-inflammatory activity through measurement of NO, COX-2, IL-1β, and TNF-α, cytotoxic effect on human neuroblastoma (SH-SY5Y) and normal hepatic (THLE2) cell lines. Here, PTGS2 is linked to Alzheimer disease.