ISG15 and metabolic dysfunction-associated steatohepatitis: In line with these findings, the lean hamsters and obese NASH hamsters did not differ in their expression of the interferon (IFN)-stimulated genes (ISGs) Isg15, the IFN-induced GTP-binding protein Mx1 on dpi 4 and 7 (Figure 2D and Supplementary Figure S3A), and the anti-inflammatory genes Infg, Il10, and Il6 (Supplementary Figure S3B–D).