Collectively, the obese NASH hamsters displayed not only the expected metabolic comorbidities (dyslipidemia and NASH/liver fibrosis) but also a pro-inflammatory profile with elevated serum levels of IL-6 and MCP-1 in the steady state, both of these inflammatory biomarkers being linked to the severity of COVID-19 in humans. This evidence concerns the gene CCL2 and metabolic dysfunction-associated steatohepatitis.