For example, Hait et al. [26] reported that missense mutations in genes encoding ATG4A and LC3B2 disrupt autophagy, resulting in increased herpes simplex virus 2 replication and susceptibility to viral infection in both primary fibroblasts and a neuroblastoma cell line, highlighting the importance of the anti-viral effect of autophagy. This evidence concerns the gene ATG4A and viral infectious disease.