In addition, transcriptomic analysis following de novo infection of peripheral blood mononuclear cells (PBMCs), CD14+ cells and telomerase immortalized vascular endothelial (TIVE) cells, revealed relative abundance of actively transcribed ORF45 mRNA at 4 h post-infection, indicating its rapid accumulation in host cells following KSHV infection [18]. This evidence concerns the gene CD14 and infection.