➢Inhibits IκB kinase β (IKKβ, IC50 = 8.5 nM ) and IKKα (IC50 = 250 nM).➢Reduces the constitutive phosphorylation of IκBα and NF-κB p65 in myeloma cells at 50 μM. ➢Prevents HIV-1 reactivation induced by TNF-α in HIV latently infected cells (IC50 = 0.56 μM). The gene discussed is TNF; the disease is plasma cell myeloma.