Since XBP1 regulates a set of genes involved in the phospholipid synthesis, we decided to address whether the ER stress-induced during the infection by ICOV and L. amazonensis would upregulate the expression of the cholinephosphotransferases CPT1 and CEPT1enzymes, which regulate the final steps of the Kennedy pathways [36]. The gene discussed is CHPT1; the disease is infection.