Immunohistochemistry of the lung granulomas of huNRG and huDRAG-A2 mice following intranasal infection with the H37Rv strain of Mtb revealed that both human CD4+ T cells and CD68+ macrophages were involved in the formation of granulomas and the containment of the mycobacterium (Figure 7D,E and Figure 8D,E). This evidence concerns the gene CD4 and infection.