CD4 and CD8 T-cell responses in lymph nodes (inguinal and brachial) and splenocytes are shown in Figure 3C. Inactivated PR8 H1N1 and M2e5x VLP + Alhydrogel® + MPL-A® BSA MPs showed heightened expression of CD4 and CD8 in T cells in spleen and lymph nodes compared to Naïve, which resembled the T-cell response to influenza infection in non-immunized mice. Here, CD4 is linked to influenza.