Thus, we first analyzed the frequency of CCR6–CXCR3+ Tc1 within ‘naïve’, CM, EM, and TEMRA CD8+ T cells in patients with acute COVID-19 (Figure 7A–D) and found that the level of Tc1 cell in all CD8+ T cell subsets decreased compared to convalescent COVID-19 individuals and healthy controls. The gene discussed is CD8A; the disease is COVID-19.