We found that the relative number of CM CD8+ T cells was increased, whereas the level of TEMRA CD8+ T cells was decreased in patients with acute COVID-19 compared to healthy controls (14.46% (9.18; 21.97) vs. 10.48% (6.98; 13.22) with p = 0.003 and 19.24% (8.43; 34.45) vs. 27.10% (16.21; 35.92) with p = 0.028, respectively), but the level of all mature CD8+ T cells was significantly lower in acute COVID-19 in comparison with convalescent-phase and healthy individuals (except CM CD8+ T cells, Figure 4). Here, CD8A is linked to COVID-19.