At the beginning, there was an increased serum IL-27 level noted in patients with acute COVID-19 compared to COVID-19 convalescents and healthy controls (4533 ng/mL (2494; 7144) vs. 1422 ng/mL (1081; 1699) and 966 ng/mL (733; 1944), respectively, p < 0.001 in both cases). This evidence concerns the gene IL27 and COVID-19.